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The cerebral arterio‐venous oxygen content differences (AVDo 2 ) during halothane and neurolept anaesthesia in patients subjected to craniotomy
Author(s) -
Engberg M.,
ØBerg B.,
Christensen K. S.,
Pedersen M. Bach,
Cold G. E.
Publication year - 1989
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1989.tb02983.x
Subject(s) - halothane , medicine , anesthesia , hemodynamics , cerebral blood flow , blood pressure
In 20 patients subjected to craniotomy for supratentorial cerebral tumours, the haemodynamic changes during halothane and neurolept anaesthesia were evaluated by measuring mean arterial blood pressure (MABP) and cerebral arterio‐venous oxygen content differences (AVDo 2 ) repeatedly during the operation. Ten patients were given 0.5% halothane anaesthesia and ten patients neurolept anaesthesia. MABP, AVDo 2 and Paco 2 were measured after induction of anaesthesia, before and after incision, after opening and closure of the dura, at the time of extubation and 1 h later. Concerning MABP and Paco 2 , no significant difference between the two groups was found. In both groups an increase in MABP was observed after incision ( P <0.01 in the neurolept group and P <0.05 in the halothane group) and in the neurolept group after extubation ( P <0.01). In both groups a decrease in AVDo 2 was observed after incision ( P <0.01) and after extubation ( P <0.01 in the neurolept group and P <0.05 in the halothane group). During the operation AVDo 2 values were significantly higher in the neurolept group ( P <0.05). The results indicate that even a moderate increase in MABP after incision during neuroanaesthesia affects AVDo 2 values, suggesting an increase in cerebral blood flow. The study suggests that autoregulation of cerebral blood flow might be better preserved during neurolept anaesthesia. A state of hyperperfusion of the brain after extubation was unveiled in both groups.