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Effects of dopamine on intestinal hemodynamics and motility during epidural analgesia in the cat
Author(s) -
Lundberg J.,
Biber B.,
Delbro D.,
Martner J.,
Werner O.
Publication year - 1989
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1989.tb02951.x
Subject(s) - dopamine , mean arterial pressure , medicine , heart rate , hemodynamics , blood pressure , anesthesia , endocrinology
The effects of dopamine on intestinal blood flow (IBF) and intestinal contraction rate (ICR), and on mean arterial pressure (MAP) and heart rate (HR) were studied in eight cats before and during epidural analgesia (EDA). Before EDA, dopamine 5 and 10 μg · kg ‐1 · min ‐1 had no effect on IBF, MAP and HR, but the higher infusion rate decreased ICR by 71 ± 19% (mean ± 1 s.e.mean) ( P <0.01). EDA significantly increased IBF when intestinal arterial pressure was maintained at an unchanged level by means of a pump, and transiently increased ICR and intestinal tone, but reduced MAP by 46 ± 8% (139 ± 11 to 75 ± 9 mmHg, P < 0.01) and HR by 26 ± 3% (248 ± 7 to 184 ± 8 beats · min ‐1 , P < 0.01). During EDA, dopamine increased IBF further, the response being similar at both infusion rates. 5 μg · kg ‐1 · min ‐1 increased HR by 26 ± 7 beats · min ‐1 ( P < 0.01) and MAP by 19 ± 9 mmHg (ns). The corresponding values at 10 μg · kg ‐1 · min ‐1 were 65 ± 14 beats · min ‐1 ( P < 0.01) and 35 ± 8 mmHg ( P <0.01), respectively. Vascular autoregulation appeared to be unaffected by dopamine and EDA. The effect of dopamine on ICR was not significantly different to what was seen before EDA. It is concluded that the effects of dopamine on IBF, MAP and HR were markedly different during EDA as compared to before the block and that ICR was reduced by dopamine, while it was transiently increased by EDA. The findings indicate that dopamine infusion is a useful way of supporting both the intestinal and the systemic circulation during EDA.