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Anesthesia with alfentanil and methohexitone for short gynecological surgery
Author(s) -
Bernstein K.,
Wirpszo R.,
Djärv L.
Publication year - 1989
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1989.tb02945.x
Subject(s) - medicine , alfentanil , anesthesia , methohexital , surgery , shivering , incidence (geometry) , heart rate , thrombophlebitis , apnea , blood pressure , propofol , physics , optics , thrombosis
An anesthetic technique in which alfentanil hydrochloride, an ultra‐short‐acting opioid, was used as a substitute for N 2 O/O 2 was evaluated in outpatient gynecological surgery. Methohexitone was used as a hypnotic agent. The following parameters were studied: blood pressure (BP) and heart rate before, during and at the end of surgery; the incidence of apnea longer than 20 s at induction; the awakening phase; immediate postoperative complications and later postoperative complications according to a questionnaire, including signs of thrombophlebitis. Eighty‐nine patients were randomly allocated to three groups. Twenty‐nine patients received alfentanil 7 μg/kg plus methohexitone plus O 2 /air (Group A7). Thirty patients received alfentanil 15 μg/kg plus methohexitone plus O 2 /air (Group A15). Thirty patients received thiopentone 5 mg/kg plus N 2 O/O 2 (Group P, reference group). Neither in the A7‐group, nor in the A15‐group was there any increase in peroperative BP, while in the P‐group both systolic and diastolic BP rose. The awakening phase was significantly shorter in both the A7‐ and A15‐groups compared to the P‐group. Apnea of clinical importance was only seen in the A15‐group. There were few immediate postoperative complications in all groups, but the incidence of dizziness was significantly higher in the P‐group. According to the questionnaire, the overall incidence of complaints the day after surgery was somewhat higher in the P‐group. On the other hand, there was a somewhat higher incidence of thrombophlebitis in both A‐groups. We may thus recommend the use of a combination of alfentanil 7 μg/kg plus methohexitone and air/oxygen for anesthesia in patients subjected to short gynecological procedures.