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Adverse effects on the brain in connection with isoflurane‐induced hypotensive anaesthesia
Author(s) -
Enlund M.,
Ahlstedt B.,
Revenäs B.,
Krekmanov L.,
Ronquist G.
Publication year - 1989
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1989.tb02935.x
Subject(s) - medicine , isoflurane , anesthesia , cerebrospinal fluid , adverse effect
As a marker of brain cell injury, adenylate kinase (AK) was measured in cerebrospinal fluid (CSF) in 10 patients given anaesthesia with isoflurane‐induced hypotension for corrective surgery of dentofacial deformities. Nine out of 10 patients displayed a marked increase in CSF‐AK postoperatively compared with preoperative values. The postoperative mean value displayed a 400% increase compared to the corresponding preoperative value. This difference was statistically significant ( P =0.001). The rise in CSF‐AK was most probably the result of an enhanced efflux of AK into CSF subsequent to a presumed hypoxic injury to brain cells.