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The influence of 0.5 % isoflurane on a vecuronium‐induced neuromuscular blockade
Author(s) -
Eriksson L. I.,
Staun P.,
Lennmarken C.
Publication year - 1989
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1989.tb02914.x
Subject(s) - isoflurane , medicine , anesthesia , neuromuscular blockade , vecuronium bromide , adductor pollicis muscle , neuromuscular transmission , ulnar nerve , bolus (digestion) , blood pressure , narcotic , neuromuscular monitoring , surgery , elbow
The influence of adding 0.5% isoflurane to a narcotic‐based anaesthesia on the duration of effect and recovery time after repetitive administration of vecuronium was studied in ten healthy patients. The twitch response in the adductor pollicis muscle was recorded after supramaximal train‐of‐four (TOF) stimulation of the ulnar nerve at the wrist. Prior to endotracheal intubation a bolus dose of vecuronium (0.08 mg/kg b.w.) was given. During surgery repeated injections of vecuronium (0.02 mg/kg b.w.) were administered at a TOF ratio of 0.25. Hand‐skin temperature, systolic blood pressure, end‐tidal CO 2 and isoflurane concentrations were continuously monitored. Before and after 90 min administration of isoflurane, the duration of effect was 21 ± 4 and 24 ± 5 min (mean ± s.d., P <0.05) respectively. Corresponding recovery times were 270 ± 60 and 280 ± 70 s (n.s.). Skin temperature remained unchanged and systolic blood pressure showed only minor variations. The addition of 0.5% isoflurane to a narcotic‐based anaesthesia causes a moderate increase in duration of effect but no change in recovery time from a repetitive vecuronium‐induced neuromuscular blockade of 0.02 mg/kg.