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The effects of prolonged isoflurane anaesthesia on cerebral blood flow and metabolism in the dog
Author(s) -
ROALD O. K.,
FORSMAN M.,
STEEN P. A.
Publication year - 1989
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1989.tb02892.x
Subject(s) - isoflurane , medicine , cerebral blood flow , anesthesia , superior sagittal sinus , hemodynamics , halothane , blood flow , cardiology , thrombosis
To determine whether cerebral blood flow (CBF) changed with time under isoflurane anaesthesia, as has been reported for halothane, CBF and cerebral metabolic rate for oxygen (CMRo 2 ) were studied in five dogs under prolonged isoflurane anaesthesia. CBF was measured with a modified sagittal sinus technique and CMRo 2 was calculated as the product of CBF and the arteriovenous O 2 difference. Maintaining this experimental dog model with 1 % isoflurane in oxygen and nitrogen for 3 h in five dogs and for 4 h in three dogs did not cause any significant changes in CMRo 2 or CBF. Cerebral metabolite levels were consistent with earlier reports from short–time studies and the EEG recordings showed a continuous sleep pattern with no pathological changes. It is concluded that there is no change in CBF or CMRo 2 in our modified sagittal outflow model during 3–4 h of 1 % isoflurane anaesthesia.