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Train–of–four fade during onset of neuromuscular block with nondepolarising neuromuscular blocking agents
Author(s) -
GIBSON F. M.,
MIRAKHUR R. K.
Publication year - 1989
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1989.tb02890.x
Subject(s) - fade , medicine , neuromuscular monitoring , anesthesia , significant difference , neuromuscular blocking agents , neuromuscular transmission , block (permutation group theory) , atracurium besilate , vecuronium bromide , neuromuscular blockade , mathematics , geometry , computer science , operating system
Fade in the train–of–four (TOF) responses during onset of neuromuscular block was studied following administration of atracurium (225 or 450 μg/kg), vecuronium (40 or 80 μg/kg), pancuronium (60 or 120 μg/kg) and tubocurarine (450 μg/kg). TOF ratios were measured at approximate heights of T, (first response in the TOF) of 75, 50 and 25%. Fade in TOF increased as the height of T 1 decreased, with maximum fade being observed at T 1 of 25%. The greatest difference between relaxants was observed at T, of 25%, vecuronium showing the least fade and pancuronium, atracurium and tubocurarine showing increasing fade, in that order. The difference between atracurium and tubocurarine or between vecuronium and pancuronium was not significant, but the degree of TOF fade was significantly greater with atracurium and tubocurarine in comparison to vecuronium or pancuronium.