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Cimetidine and ranitidine do not affect enflurane metabolism in surgical patients
Author(s) -
OIKKONEN M.,
ROSENBERG P. H.,
SAARNIVAARA L.
Publication year - 1989
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1989.tb02874.x
Subject(s) - medicine , cimetidine , enflurane , ranitidine , affect (linguistics) , metabolism , pharmacology , anesthesia , isoflurane , linguistics , philosophy
Hepatic cytochrome–P–450–linked microsomal metabolism is inhibited by cimetidine, and to a lesser extent by ranitidine. Such an inhibition might protect against the metabolite–related toxicity of inhalation anesthetics. However, in comparison with the values measured in a control group, neither cimetidine (600 mg p.o. + 200 mg i.m.) nor ranitidine (150 mg p.o. + 50 mg i.m.), both administered 11–12 h and 1 h before anesthesia, inhibited enflurane metabolism as assessed by the increase in plasma inorganic fluoride concentration and urinary fluoride excretion in 21 ASA I patients anesthetized with enflurane (end–tidal concentration 0.5 0.05% for 2–6 h). The inorganic fluoride concentration in the gastric juice remained low in all groups.