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Hepatic drug disposition in multiple organ failure
Author(s) -
Schregel W.,
Kuntz H.D.,
Vitt M.
Publication year - 1988
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1988.tb02801.x
Subject(s) - medicine , drug , indocyanine green , theophylline , drug metabolism , disposition , etiology , glucuronidation , intensive care medicine , pharmacology , surgery , psychology , social psychology , biochemistry , chemistry , enzyme , microsome
In 15 patients with multiple organ failure of septic etiology, some principal partial hepatic functions of drug disposition were measured by the test substances galactose, indocyanine green, theophylline and 4‐methylumbelliferon. Glucuronidation was not impaired in any case, whereas flow‐limited and capacity‐limited drug elimination can be influenced. Drug monitoring and intense clinical observation seem necessary to improve drug therapy and the outcome of patients with multiple organ failure.