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Buprenorphine antagonism of ventilatory depression following fentanyl anaesthesia
Author(s) -
Boysen K.,
Hertel S.,
Jørgensen B. Chræmmer,
Risbo A.,
Poulsen N. J.
Publication year - 1988
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1988.tb02772.x
Subject(s) - medicine , anesthesia , buprenorphine , fentanyl , sedation , respiratory rate , (+) naloxone , respiratory system , depression (economics) , opioid , heart rate , blood pressure , receptor , economics , macroeconomics
In order to compare the effect of buprenorphine and naloxone on respiratory depression after fentanyl anaesthesia (25 μg/kg), 32 women scheduled for elective abdominal hysterectomy participated in a doubleblind randomized investigation. At termination of anaesthesia, after antagonizing residual neuromuscular blockade, 20 normocapnic patients with a respiratory rate of 4 breaths/min or less entered the study, receiving either buprenorphine (0.6 mg in 20 ml NaCl) or naloxone (0.4 mg in 20 ml NaCl) 2 ml/min until 20 ml was given or until the respiratory rate exceeded 8 breaths/min. Respiratory rate, Pacc>2, sedation score, and pain intensity were evaluated during a 3–h study period. Fifteen min after beginning the treatment, all the patients in both groups had their ventilatory depression antagonized. There were no statistically significant differences in respiratory rates between groups except at 15 min. On no occasion did either Paco2 or a sedation score differ statistically significantly between the groups. At 15 min all patients in the buprenorphine group had no or mild pain, compared to the patients in the naloxone group, of whom 50% had moderate to severe pain (P < 0.05). It seems as if bupenorphine is as effective as naloxone in antagonizing respiratory rate depression following fentanyl anaesthesia.