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Neostigmine and edrophonium as antagonists of atracurium and pancuronium
Author(s) -
Sanfilippo M.,
Vilardi V.,
Fierro G.,
Rosa G.,
Pelaia P.,
Gasparetto A.
Publication year - 1988
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1988.tb02762.x
Subject(s) - neostigmine , edrophonium , medicine , neuromuscular blockade , anesthesia , blockade , myasthenia gravis , stimulation , atracurium besilate , neuromuscular transmission , neuromuscular monitoring , receptor
Edrophonium 0.5 mg/kg or neostigmine 0.04 mg/kg were administered to two groups of 30 patients each for antagonism of atracurium– or pancuronium–induced neuromuscular block at 25% single twitch recovery. Neuromuscular block was studied using both single twitch and train–of–four (TOF) nerve stimulation. The times to 100% single twitch recovery were significantly more rapid for patients receiving edrophonium ( P < 0.01) in both groups (atracurium and pancuronium); the TOF ratios were similar for atracurium, but for pancuronium they were greater after neostigmine than after edrophonium, and only at 25 min were these ratios similar. It is concluded that edrophonium in a dose of 0.5 mg/kg antagonizes neuromuscular blockade induced by atracurium, as does neostigmine in a dose of 0.04 mg/kg, but the former does not consistently antagonize neuromuscular blockade induced by pancuronium even at 25% of single twitch recovery.