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Reversal of flunitrazepam sedation with flumazenil. A randomized clinical trial
Author(s) -
Riishede L.,
Krogh B.,
Nielsen J. Lyhne,
Freuchen I.,
Mikkelsen B. O.
Publication year - 1988
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1988.tb02761.x
Subject(s) - flumazenil , flunitrazepam , medicine , sedation , anesthesia , placebo , benzodiazepine , anterograde amnesia , randomized controlled trial , adverse effect , amnesia , surgery , psychiatry , receptor , alternative medicine , pathology
Fifty–nine male patients scheduled for transurethral resection of the prostate under flunitrazepam sedation and spinal analgesia were randomized in a double–blind trial to reversal of sedation with either the benzodiazepine antagonist flumazenil or placebo. Judged by degree of sedation, comprehension and cooperation as well as by estimation of orientation in time and space, flumazenil was superior to placebo ( P < 0.001). The median duration of anterograde amnesia was 16 min after flumazenil and 75 min after placebo ( P < 0.001). Adverse events were more frequent with placebo ( P > 0.05), while no differences were evident with regard to laboratory data or cardiorespiratory function.