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Fluctuating PEEP (F–PEEP) versus conventional PEEP in dogs with asymmetrical lung injury
Author(s) -
Inaba H.,
Sato J.,
Uchida H.,
Sakurada M.,
Ohwada T.,
Mizuguchi T.
Publication year - 1988
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1988.tb02748.x
Subject(s) - medicine , positive end expiratory pressure , anesthesia , pulmonary compliance , lung , artificial ventilation , mechanical ventilation , respiratory disease
Fluctuating PEEP (F–PEEP) is a newly developed PEEP in which end–expiratory pressure (EEP) is periodically changed within a certain range. In a dog model with unilateral lung injury induced by the introduction of hydrochloric acid, F–PEEP in which the EEP was periodically changed from 0.5 to 1.5 kPa at periods of 6 min, and conventional PEEP (C–PEEP) with an optimized EEP of 1.0 kPa, were each applied for 30 min. F–PEEP produced a significantly greater improvement of Pao 2 and intrapulmonary shunt (Qs/Qr)than C–PEEP, and at the low EEP phase, the greatest improvement accompanied by an increased dynamic compliance and a large cardiac output was obtained. These results suggest that F–PEEP provides a useful mode of artificial ventilation for the treatment of unilateral lung injury.