Premium
Comparison between fluctuating PEEP and conventional PEEP in dogs with lung injury induced by blood aspiration
Author(s) -
Sato J.,
Inaba H.,
Uchida H.,
Sakurada M.,
Ohwada T.,
Mizuguchi T.
Publication year - 1988
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1988.tb02747.x
Subject(s) - medicine , lung , anesthesia , positive end expiratory pressure
It has been documented that in some patients with acute hypoxic respiratory failure the application of positive end–expiratory pressure (PEEP) may produce no improvement or even a deterioration of pulmonary oxygenation due to an increase in ventilation–perfusion mismatching. Fluctuating PEEP (F–PEEP) is a newly developed PEEP in which end–expiratory pressure (EEP) is periodically changed within a certain range. In a dog model with localized lung injury induced by the aspiration of non–heparinized blood (2 ml kg body weight ‐1 ), F–PEEP in which the EEP was periodically changed from 0.5 to 1.5 kPa at frequencies of 10 min, and conventional PEEP with 3 different fixed EEPs, 0.5, 1.0 and 1.5 kPa (C–PEEP 0.5 , C–PEEP 1.0 and C–PEEP 1.5 ) were each applied for 60 min. F–PEEP produced a periodical change in Pao 2 and hemodynamic variables including cardiac output, and in comparison with C–PEEP 0.5 , C–PEEP 1.0 and C–PEEP 1.5 , a signficiantly greater improvement of A–aDo 2 and dynamic compliance with relatively largecardiac output in the low EEP phase. These results suggest that F–PEEP is a useful mode of artificial ventilation for treating some kinds of acute hypoxic respiratory failure due to increased ventilation–perfusion mismatching.