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Effects of isoflurane on myocardial metabolism during postischaemic reperfusion in the rat
Author(s) -
Kashimoto S.
Publication year - 1988
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1988.tb02714.x
Subject(s) - isoflurane , medicine , perfusion , glycogen , ischemia , cardiology , metabolism , anesthesia
In experiments on isolated rat heart lung preparation, the effects of isoflurane on myocardial metabolism during postischaemic reperfusion were evaluated with intramyocardial high energy phosphates, lactate and glycogen. Hearts were perfused for 10 min initially and made globally ischaemic for 8 min in ischaemic groups. Afterwards, they were reperfused for 12 min. Isoflurane was administered from 5 min after the start of perfusion to the end of reperfusion. There was no significant difference in myocardial lactate levels between ischaemic isoflurane and control groups. However, the ATP level in the hearts in the ischaemic isoflurane group was significantly higher than that in the ischaemic control group (17.96 ±1.31 vs 15.50 ± 0.87; P < 0.005). The administration of isoflurane to the isolated rat heart during pre– and post–ischaemia enhanced metabolic recovery in the postischaemic state.