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The influence of alfentanil on the intubating conditions after priming with vecuronium
Author(s) -
Hei.BoHansen S.,
Ravlo O.,
Andersen S. Trap
Publication year - 1988
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1988.tb02685.x
Subject(s) - alfentanil , medicine , anesthesia , intubation , neuromuscular blockade , priming (agriculture) , incidence (geometry) , tracheal intubation , neuromuscular transmission , propofol , optics , biology , botany , germination , physics
The ability of alfentanil 15 μg kg ‐1 or 30 μg kg ‐1 to improve intubating conditions was studied in four groups of 25 ASA class 1 patients. Induction of anaesthesia was with thiopentone 5 mg kg ‐1 . Neuromuscular blockade was induced with vecuronium using the priming principle. The priming dose, priming interval and intubating dose were 0.01 mg kg ‐1 , 4 min, and 0.1 mg kg ‐1 , respectively. Intubation was attempted 1 min after the intubating dose. Intubating conditions were judged unacceptable in about 30% of the patients belonging to the control groups. Alfentanil 15 μg kg ‐1 , when administered 65 s before intubation, reduced the incidence of coughing and diaphragmatic movement ( P <0.05) but did not reduce the incidence of overall unacceptable intubating conditions. Alfentanil 30 ug kg ‐1 , however, reduced the incidence of vocal cord movement ( P <0.005) as well as coughing and diaphragmatic movement ( P <0.002). Alfentanil 30 ug kg ‐1 reduced the incidence of unacceptable intubating conditions from about 30% to 4% ( P <0.02).