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The volatile anesthetics, halothane, enflurane and isoflurane, influence the distribution of thiopental in man differently
Author(s) -
Altmayer P.,
Bügh U.,
Hutschenreuter K.,
Bügh H. P.
Publication year - 1987
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1987.tb02659.x
Subject(s) - enflurane , halothane , isoflurane , medicine , anesthesia , anesthetic , pharmacokinetics , inhalation , volume of distribution , nitrous oxide , thiopental sodium , distribution (mathematics) , pharmacology , propofol , mathematical analysis , mathematics
In man, a change of thiopental pharmacokinetics was observed under halothane anesthesia, but not when patients were anesthetized with enflurane and isoflurane. After an initial subancsthetic dose of 50 mg thiopental, the concentrations in serum (T) were determined over 15 min (4 samples). From these T‐valucs the pharmacokinetic parameters V c (central volume of distribution), t ½ α and Cl were established (control). 16 min after the first thiopental dose, one of the inhalation anesthetics was administered (randomized). After 45 min exposure to the respective inhalation anesthetic (2–3 MAC in combination with N 2 O, steady‐state) a second dose of 50 mg thiopental was injected and the T‐values were determined again over 15 min. The T‐values of the control course varied considerably; the logarithmic frequency distribution revealed two distinct subgroups of patients, A and B, with characteristic V c and t ½ α. Both subgroups were influenced by the volatile anesthetics in a similar way with regard to pharmacokinetic parameters. With halothane, V c was decreased and t ½ α was shortened. In contrast, enflurane and isoflurane did not affect the pharmacokinetic parameters.