Premium
Effect of chronic bupivacaine infusion on seizure threshold to bupivacaine
Author(s) -
Skeie B.,
Dodgson M. S.,
Forsman M.,
Steen P. A.
Publication year - 1987
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1987.tb02595.x
Subject(s) - bupivacaine , medicine , tachyphylaxis , anesthesia , blockade , placebo , local anesthetic , pharmacology , receptor , alternative medicine , pathology
Thirty rats were pretreated with a continuous infusion of bupivacaine or placebo. On the fourth day the acute seizure threshold to bupivacaine was determined for both groups. The seizure dose, blood and brain concentration of bupivacaine showed no difference between the groups. The tachyphylaxis seen clinically when bupivacaine is used for a regional nerve blockade does not seem to evolve for the CNS‐effects.