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Effects of repeated doses of benzodiazepines on arterial blood gases and transcutaneous Po 2
Author(s) -
Eriksson I.,
Berggren L.
Publication year - 1987
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1987.tb02584.x
Subject(s) - midazolam , medicine , anesthesia , diazepam , (+) naloxone , crossover study , arterial blood , benzodiazepine , opioid , sedation , receptor , alternative medicine , pathology , placebo
The effects of repeated doses of benzodiazepines, diazepam and midazolam in combination with meperidine. on arterial blood gases and transcutaneous Po 2 were studied in eight healthy volunteers. The study was designed to mimic a clinical situation. Initially two doses of either midazolam 0.05 mg/kg or diazepam in fat emulsion 0.15 mg/kg were given in a randomized crossover fashion with a 20‐min interval, followed by meperidine 0.5 mg/kg another 20 min later. The opioid effects were then antagonized by naloxone 0.4 mg. The initial doses of benzodiazepines caused an increase in Paco 2 and a decrease in Pao 2 . The changes in Pao 2 were of short duration and recovered to baseline levels between injections. However, they came sooner and were more pronounced after midazolam. The changes in P tc o 2 paralleled those in Pao 2 . The P tc O 2 index as a measure of cardiac output and peripheral blood flow adequacy was increased immediately after the first injection of midazolam but was otherwise not different from control. There were no differences between the drugs concerning P tc O 2 index. Paco 2 increased after the first benzodiazepine injection and remained so throughout the study. Addition of meperidine caused only small changes in Pao 2 and Paco 2 . These changes were recieved by naloxone. In spite of different elimination kinetics there was no difference in the duration of respiratory depression between the two benzodiazepines.