Premium
Neutrophil mobility during anaesthesia in children. A trial of ascorbate premedication
Author(s) -
Charlton A. J.,
Harvey B. A.,
Hatch D. J.,
Soothill J. F.
Publication year - 1987
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1987.tb02580.x
Subject(s) - medicine , premedication , anesthesia
In 20 healthy children undergoing elective surgery, mobility of neutrophils, both unstimulated and stimulated by endotoxin, was studied using a millipore filter system with microscopic determination of leading front migration. Paired samples were incubated with 10 ‐2 mol l ‐1 calcium ascorbate and ten children also received 10 mg kg ‐1 ascorbic acid before premedication. Stimulation of mobility was reduced after the opioid premedication ( P < 0.05) in the ascorbate group only, hut not significantly during anaesthesia and surgery. A few individuals showed persisting abnormally low values. No effect of ascorbate in vivo or in vitro was demonstrated. There were no infrations.