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Effects of rectal thiopentone and methohexitone on carbon dioxide tension in infant anaesthesia with spontaneous ventilation
Author(s) -
Larsson L. E.,
Nilsson K.,
Andreasson S.,
EkströmJodal B.
Publication year - 1987
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1987.tb02556.x
Subject(s) - medicine , anesthesia , premedication , halothane , nitrous oxide , barbiturate , methohexital , rectal administration , general anaesthesia , ventilation (architecture) , propofol , mechanical engineering , engineering
The influence of rectal administration of barbiturates on Pco 2 during mask anaesthesia with spontaneous ventilation was studied in 72 infants. The age of the patients ranged between 6 and 24 months and they were all subjected to minor paediatric surgery. The patients were divided into four equally large groups: a control group receiving no premedication, a group receiving rectal thiopentone 30 mg·kg ‐1 and two groups receiving methohexitone either 20 or 30 mg·kg ‐1 . In all patients Pco 2 was measured in an arterialized capillary blood sample obtained during stable anaesthesia with oxygen, nitrous oxide and halothane before and after surgery. After rectal induction with barbiturates, the mean Pco 2 was significantly higher in the different barbiturate groups than in the control group ( P <0.05). The mean Pco 2 value ± s.d. in kPa for the control group was 5.6 ± 0.7, for the group receiving thiopentone 30 mg·kg ‐1 6.5 ± 1.6, for the groups receiving methohexitone 20 or 30 mg·kg ‐1 6.1 ± 1.2 and 6.3 ± 1.1, respectively. It is concluded that the combination of rectal induction with barbiturates and mask anaesthesia with oxygen, nitrous oxide and halothane carries an increased risk of hypoventilation in infants under 2 years of age.