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Atracurium infusion in total intravenous anesthesia
Author(s) -
Nilsson A.,
Tamsen A.,
Persson M. P.
Publication year - 1987
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1987.tb02551.x
Subject(s) - medicine , anesthesia , intravenous regional anesthesia , regional anesthesia
The neuromuscular blocking effect of atracurium given as a bolus dose (0.5 mg·kg ‐1 ) followed by a maintenance infusion was studied during two different anesthetic techniques. It has been reported that benzodiazepines interact with non‐depolarising neuromuscular blockers. In this study no difference was found in the effect of atracurium given with conventional fentanyl/nitrous oxide anesthesia when compared to total intravenous anesthesia using midazolam/alfentanil. More than 90% twitch depression was achieved after 123 and 137 s, respectively. Recovery time to 10% twitch height following the bolus dose was around 32 min. The dosage range for atracurium given by infusion (0.29‐0.44 mg·kg ‐1 · ‐1 ) was confirmed.