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Effects of halothane and enflurane on myocardial metabolism during postischaemic reperfusion in the rat
Author(s) -
Kashimoto S.,
Tsuji Y.,
Kumazawa T.
Publication year - 1987
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1987.tb02518.x
Subject(s) - enflurane , halothane , medicine , perfusion , anesthesia , glycogen , metabolism , energy metabolism , cardiology , endocrinology
In experiments on isolated rat heart‐lung preparation, the effects of halothane and enflurane on myocardial metabolism during postischaemic reperfusion were evaluated with intramyocardial high energy phosphates, lactate and glycogen. Hearts were perfused for 10 min initially and made globally ischacmic for 8 min. Afterwards, they were reperfused for 12 min. Halothane or enflurane was administered from 5 min after the start of perfusion to the end of reperfusion. There were no significant differences in contents of high energy phosphates between control (C), halothane (H) and enflurane (E) groups (ATP: 15.50 ± 0.87, 16.05 ± 1.99 and 15.16 ± 2.03 μmol/g dry wt, respectively). However, lactate levels in the hearts in Groups H and E were significantly higher than those in Group C (44.04 ± 10.54, 40.63 ± 10.34 vs 28.63 ± 5.98). Slight deterioration in the myocardial oxidation‐reduction state may be caused by inhalational anaesthetics when they are administered during the postischaemic reperfusion period.