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Selective effect of sufentanil on Group III (A delta) and Group IV (C) somatosympathetic reflexes
Author(s) -
Swenzen G. Odensjo,
Chakrabarti M.,
SapsedByrne S.,
Wnrrwam J. G.
Publication year - 1986
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1986.tb02472.x
Subject(s) - medicine , sufentanil , reflex , anesthesia , group (periodic table) , organic chemistry , chemistry
The effect of sufentanil on somatosympathetic reflexes and the subsequent reversal of its effects by naloxonc have been observed in dogs anaesthetised with a‐chloralose, paralysed with suxamethonium and artificially ventilated. When the drug was infused at a rate of 2.5 μg kg ‐l min ‐1 the late long latency response evoked by Group IV (C) fibres was totally abolished at a mean dose of 6.40 pg kg ‐1 (± 0.99 μg kg‐ 1 ) (s.e. mean), while retaining a substantial part of the early short latency response evoked by group III (A delta) fibrrs; subsequently, during the infusion, this response was also totally abolished at a mean dosr of 26.2 pg kg ‐1 (±3.2 mg kg ‐1 ). The administration of naloxone (2 mg i.v.) completely reversed the effects of sufentanil within 3–5 min in different preparations. Some of the implications of these results are discussed.