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Halothane hepatitis in a prospective study of postoperative complications
Author(s) -
Zaric D.,
Larsen S. F.,
Jacobsen E.,
Olesen K. H.,
Ranek L.
Publication year - 1986
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1986.tb02469.x
Subject(s) - medicine , halothane , incidence (geometry) , prospective cohort study , hepatitis , anesthesia , surgery , physics , optics
In a prospective study comprising 2609 consecutive surgical patients, of whom 1166 were anesthetized with halothane, four cases of hapatitis were encountered. The incidence of hepatitis among those who received halothane was 1 :292 in our material. The high incidence may be explained by the recognition of milder forms of hepatitis and by the selection of the series (over 40 years). Serum alanine amiriotrarisfcrase should be investigated in all patients with postoperative pyrexia of unknown origin if mild forms of halothanc hepatitis are to be discovered. The patient's history should be carefully examined for prrvious postoperative pyrexia of unknown origin following halothane anesthesia, in which case other anethetics should be chosen.