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Positive‐pressure ventilation at moderately high frequency in newborn infants with respiratory distress syndrome (IRDS)
Author(s) -
Sedin G.
Publication year - 1986
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1986.tb02467.x
Subject(s) - medicine , respiratory distress , anesthesia , ventilation (architecture) , high frequency ventilation , bronchopulmonary dysplasia , insufflation , oxygenation , gestational age , intermittent mandatory ventilation , pneumothorax , artificial ventilation , respiratory minute volume , mechanical ventilation , respiratory system , surgery , lung , respiratory disease , pregnancy , mechanical engineering , biology , engineering , genetics
In 24 seriously ill newborn infants with respiratory distress syndrome (IRDS) and ensuing respiratory failure., high‐frequency positive‐pressure ventilation was administered. The mean gestational age of the infants was 32 ± 3 weeks. In the infant ventilator employed, the compressible volume had been reduced in order to give higher flow rates but lower intratracheal pressures. The ventilation frequency was kept constant at 60—66 per min and the insufflation period at 32–35% of the ventilatory cycle. A positive end‐expiratory pressurc (PEEP) of 0.2—0.6 kPa was used. Arterial P CO2 was maintained at 4.0–5.3 kPa and Po 2 at 8.5—10.5 kPa by adjusting the gas flow through the patient circuit, the peak tubing pressure, the PEEP and the oxygen concentration in inspired gas. High‐frequency positive‐pressure ventilation improved oxygenation and gave adequate alveolar ventilation in all infants, in most cases at a low peak pressure. Only one infant developed pneumothorax during intermittent positive pressure ventilation, and in no infant did bronchopulmonary dysplasia or retrolental fibroplasia occur. One infant died from intracranial haemorragc during the ventilation period, giving a survival rate of 96%.