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Glycopyrrolate during ketamine/diazepam anaesthesia A double‐blind comparison with atropine
Author(s) -
Mogensen F.,
Müller D.,
Valentin N.
Publication year - 1986
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1986.tb02425.x
Subject(s) - glycopyrrolate , medicine , anesthesia , heart rate , atropine , blood pressure , neostigmine , vomiting , diazepam , ketamine , nausea
In a double‐blind study, the effects of atropine and glycopyrrolate (dosage ratio 2:l) following i.m. and i.v. administration were compared with respect to salivation, heart rate, and blood pressure before, during and after i.v. infusion anaesthesia with ketamine and diazepam for alloplastic hip or knee surgery in 30 patients above the age of 50 years. Given with the premedicant, the two drugs were equally effective in reducing salivation. A slight increase in heart rate was seen after atropine only ( P <0.005). Increases in heart rate and blood pressure during induction of anaesthesia were similar in the two groups. A second dose of the test drug was given with neostigmine for reversal of neuromuscular blockade. Again, there were no statistically significant differences with respect to salivation, blood pressure, heart rate, nausea and/or vomiting, unpleasant dreams and arousal time.