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Circulatory effects of carbon dioxide in experimental endotoxic shock
Author(s) -
LARSSON L. E.,
EKSTRÖMJODAL B.
Publication year - 1986
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1986.tb02365.x
Subject(s) - medicine , cardiac output , stroke volume , anesthesia , mean arterial pressure , shock (circulatory) , heart rate , pulmonary artery , circulatory system , mean circulatory filling pressure , vascular resistance , blood pressure , mean blood pressure , aortic pressure , hemodynamics , cardiology , central venous pressure
In seven anaesthetized dogs the central circulatory effects of changes in Paco 2 were studied before and after an intravenous injection of E. coli endotoxin 1.0 mg kg ‐1 . The animals were on controlled ventilation with constant minute volumes, and Paco 2 was changed by variations in the inspired gas mixture. Before endotoxin was given, cardiac output, mean aortic pressure, mean pulmonary artery pressure, total peripheral resistance and stroke volume were little affected by the changes in Paco 2 from 3.9 0.4 to 7.2 0.4 kPa (mean s. e. mean). Only heart rate decreased significantly ( P <0.05). The intravenous endotoxin injection resulted in a decreased cardiac output ( P <0.01), a decreased mean aortic pressure ( P <0.01) and a decreased stroke volume ( P <0.05). Mean pulmonary artery pressure, total peripheral resistance and heart rate showed only minor changes. In endotoxic shock an increase in PaCO 2 from 4.4 0.4 to 7.8 0.3 kPa (mean s. e. mean) resulted in a significant increase in cardiac output ( P <0.05), stroke volume ( P <0.05) and mean pulmonary artery pressure ( P <0.05), while the other parameters remained unchanged. It can be concluded that the carbon dioxide tension is of importance for the cardiac performance in experimental endotoxic stock in a manner not seen in control animals. The mechanisms behind these findings need further investigation.