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The Effects of Naloxone on Central Hemodynamics and Myocardial Metabolism in Experimental Propoxyphene‐Induced Circulatory Shock
Author(s) -
Strøm J.,
Häggmark S.,
Madsen P. S.,
Östman M.,
Reiz S.,
Angelo H.,
Sørensen M. Bredgaard
Publication year - 1985
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1985.tb02282.x
Subject(s) - medicine , propoxyphene , (+) naloxone , hemodynamics , anesthesia , shock (circulatory) , circulatory system , pentobarbital , opioid , analgesic , receptor
The courses of the hemodynamic and cardiometabolic effects of naloxone were evaluated in propoxyphene‐induced shock in eight pentobarbital‐anesthetized pigs. Circulatory shock was induced by an infusion of propoxyphene chloride 15 mg·min ‐1 i.v. At shock, i.e. MAP<60 mmHg and/or CI<2.0 l·min ‐1 ·m ‐2 , naloxone was administered at 0.75, 1.5 and 3.0 mg·kg ‐1 with an interval between increments of 8 min. The propoxyphene infusion of 15 mg·min ‐1 was continued throughout the study. Following the injection of naloxone 0.75 mg·kg ‐1 , increases were observed (% of baseline value) in MAP (41%), i.e. deficit to baseline 59%, HR (66%), CI (67%) and SVI (108%), whereas MPAP and MPAOP were unchanged. dP/dt increased (34%). In the coronary circulation naloxone initiated the following changes: CSF increased (69%) as did MVo 2 (48%) with unchanged Mo 2 ‐extraction, but CVR decreased further (36%). The maximum effects of naloxone were registered 2–3 min after 0.75 mg·kg ‐1 . Following 1.5 and 3.0 mg·kg ‐1 , no changes in hemodynamics were observed other than those caused by progressing propoxyphene intoxication.