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Circulatory Effects of Haemorrhage during Sodium Nitroprusside Induced Hypotension A Study in the Rat
Author(s) -
GUSTAFSON C.,
ARONSEN K. F.,
ROSBERG B.
Publication year - 1985
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1985.tb02243.x
Subject(s) - medicine , sodium nitroprusside , cardiac output , blood pressure , anesthesia , heart rate , renal blood flow , hemodynamics , blood flow , mean arterial pressure , circulatory system , cerebral blood flow , cardiology , nitric oxide
The haemodynamic changes induced by acute moderate blood loss were investigated in rats during normotensive halothane anaesthesia and during sodium‐nitroprusside‐induced hypotensive anaesthesia, respectively. Following haemorrhage in the normotensive group, mean arterial blood pressure, heart rate and left cardiac work decreased. Cardiac output was reduced non‐significantly. Blood flow was redistributed to favour cerebral, coronary, renal and hepatic circulation, mainly at the expense of blood flow to the carcass. Following haemorrhage in the hypotensive group, cardiac output increased significantly. Mean arterial pressure, heart rate and left cardiac work were unchanged. Absolute values for cerebral, coronary, renal and hepatic blood flow were maintained or even increased, while blood flow to the carcass was unchanged.