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CBF and CMR O2 during Continuous Etomidate Infusion Supplemented with N 2 O and Fentanyl in Patients with Supratentorial Cerebral Tumour. A Dose‐Response Study
Author(s) -
COLD G. E.,
ESKESEN V.,
ERIKSEN H.,
AMTOFT O.,
MADSEN J. B.
Publication year - 1985
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1985.tb02240.x
Subject(s) - etomidate , medicine , fentanyl , anesthesia , nitrous oxide , craniotomy , continuous infusion , propofol
In 14 patients with supratentorial cerebral tumours with midline shift below 10 mm, CBF and CMR o2 were measured (Kety & Schmidt) during craniotomy. The anaesthesia was continuous etomidate infusion supplemented with nitrous oxide and fentanyl. The patients were divided into two groups. In Group 1 etomidate infusion of 30 μg kg ‐1 min ‐1 was used throughout the anaesthesia, and CBF and CMR o2 were measured twice. In this group CMR o2 (± s. d.) averaged 2.31±0.43 ml O 2 100 g ‐1 min ‐1 70 min after induction and 2.21 ± 0.38 ml O 2 100 g ‐1 min ‐1 130 min after induction. In Group 2 the etomidate infusion was increased from 30 to 60 μg kg ‐1 min ‐1 after the first study and a significant fall in CMR o2 from 2.52 ± 0.56 to 1.76 ± 0.40 ml O 2 100 g ‐1 min ‐1 was found. Simultaneously, a significant fall in CBF was observed. The CO 2 reactivity was preserved during anaesthesia.