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The Pharmacokinetics of Methohexital in Young and Elderly Subjects
Author(s) -
GHONEIM M. M.,
CHIANG C. K.,
SCHOENWALD R. D.,
LILBURN J. K.,
DHANARAJ J.
Publication year - 1985
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1985.tb02237.x
Subject(s) - methohexital , medicine , enflurane , pharmacokinetics , anesthesia , nitrous oxide , bolus (digestion) , intravenous bolus , plasma concentration , surgery , halothane , pharmacology , propofol
The pharmacokinetics of methohexital were investigated in ten young adult volunteers and in seven young and seven elderly patients. The latter two groups underwent enflurane and nitrous oxide anesthesia and surgery. Each subject received a bolus dose of 2 mg/kg of methohexital intravenously. Plasma levels of the drug were measured for 8 h after injection by gas chromatography using a nitrogen detector. Anesthesia (combined with surgery) and increase in age did not separately affect the kinetics of the drug; however, the elimination half‐life was longer in the elderly patients group than in the young non‐anesthetized volunteers.