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Effect of Selective PEEP on Pulmonary Blood Flow following Unilateral Hydrochloric Acid Aspiration in the Dog
Author(s) -
TAKASAKI M.,
KAWASAKI H.,
KOSAKA Y.
Publication year - 1985
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1985.tb02223.x
Subject(s) - medicine , positive end expiratory pressure , lung , anesthesia , perfusion , cardiac output , venous blood , blood flow , hemodynamics , mechanical ventilation , cardiology
We investigated the effect of unilateral or bilateral positive end‐expiratory pressure (PEEP) on pulmonary perfusion in 12 dogs with a hydrochloric acid aspiration injury of the left lung. The lungs were ventilated separately and PEEP was applied to the left lung at 10 cm H 2 O (1.0 kPa) in six and at 15 cmH 2 O (1.5 kPa) in six others. Measurements of the right and left pulmonary arterial blood flows (Q R and Q L .) and venous admixture were made before, during and after PEEP. After this study, 5 and 10 cmH 2 O (0.5 and 1.0 kPa) PEEP were applied to both lungs in six dogs and measurements were repeated. Following the application of PEEP to the left lung, a significant decrease in Q J . and increase in Q R were observed. However, the application of PEEP to both lungs was followed by significant decreases in both Q J and Q R . The cardiac output decreased slightly during unilateral PEEP and markedly during bilateral PEEP. The venous admixture decreased significantly during PEEP in all the groups. These findings indicate that selective PEEP causes a transfer of pulmonary blood flow from the injured lung to the normal lung, improving ventilation‐perfusion inequality, and improves gas exchange without impeding oxygen delivery.