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Effects of Prenalterol and Volume Loading with Dextran on Haemodynamics and Oxygen Consumption in Dogs During High Epidural Block with Special Reference to the Splanchnic Region
Author(s) -
GREITZ T.,
ANDREEN M.,
IRESTEDT L.
Publication year - 1985
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1985.tb02156.x
Subject(s) - medicine , anesthesia , cardiac output , hemodynamics , splanchnic , vascular resistance , blood volume , central venous pressure , epidural administration , lumbar , epidural block , mean arterial pressure , heart rate , blood pressure , bupivacaine , surgery
High lumbar epidural block was induced in seven dogs, causing a fall in mean arterial blood pressure (AP) from 24.5 ⋅ 2.9 to 12.0 ⋅ 3.1 kPa owing to reductions in cardiac output (Q T ) and systemic vascular resistance (SVR) to 67% and 68% of the pre‐epidural values. Volume loading with dextran 10 ml ⋅ kg ‐1 b. w. increased Q T nearly to the pre‐epidural value. SVR decreased further to 61% of the pre‐epidural value and AP was only slightly increased to 14.9 ⋅ 2.7 kPa. Subsequent administration of prenalterol 20 μg ⋅ kg ‐1 b. w. caused a further increase in Q T to 17% above the pre‐epidural value due to an increase in heart rate of 51 beats/min. AP did not change since SVR decreased further to 49% of the pre‐epidural value. The hepatic arterial blood flow (Q HA ) was essentially unchanged during epidural block as well as during volume loading, while the portal venous blood flow (Q PV ) was changed concurrently with (Q T ). In spite of the decrease in SVR, the preportal and hepatic arterial vascular resistances were not diminished following prenalterol. The increase in Q T must therefore have favoured other vascular beds. Hepatic and pre‐portal tissue oxygen uptakes were unchanged during the experimental procedure, while whole‐body oxygen uptake decreased by 20% following the epidural block and increased nearly to the pre‐epidural level following volume loading in combination with prenalterol.