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Circulatory Effects of Pancuronium and Alcuronium in Patients with Coronary Artery Stenosis
Author(s) -
ÖHQVIST G.,
SETTERGREN G.,
TUPPURAINEN T.,
LINDSKOG E. ANJOU,
FISCHERSTRÖM A.,
TORSSELL L.,
WEDELIN B.,
WICKERTS C. J.
Publication year - 1985
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1985.tb02153.x
Subject(s) - medicine , fentanyl , anesthesia , pancuronium bromide , intubation , blood pressure , heart rate , circulatory system , diazepam , tracheal intubation , cardiology
Heart rate and systemic arterial blood pressure were recorded during induction of anaesthesia up to 9 min after endotracheal intubation in 92 patients scheduled for coronary artery bypass surgery, in order to study to what degree the circulatory response to induction of anaesthesia and intubation was modified by different relaxants. Pancuronium (pancuronium bromide) 0.1 mg ⋅ kg b. w. ‐1 and alcuronium (diallyl‐nortoxiferine) 0.25 mg ⋅ kg b. w. ‐1 were randomly studied in 36 patients during induction with high‐dose fentanyl and in 36 patients induced with thiopentone, diazepam, fentanyl and nitrous oxide. In patients given high‐dose fentanyl anaesthesia, systolic blood pressure before, during and after intubation was significantly lower with alcuronium ( P <0.01). The same difference between alcuronium and pancuronium was observed in balanced anaesthesia before endotracheal intubation. Induction of anaesthesia and intubation were followed by a moderate increase in heart rate, irrespective of the type of anaesthesia and relaxant. Subsequently, 20 patients (10 with high‐dose fentanyl and 10 with balanced anaesthesia) were studied. They received pancuronium 0.05 mg ⋅ kg b. w. ‐1 +alcuronium 0.125 mg ⋅ kg b. w. ‐1 . This mixture of relaxants produced an intermediate blood pressure response.