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The Influence of Anticoagulation on Acid‐Base Status and Blood‐Gas Analysis
Author(s) -
Börner U.,
Müller H.,
Höge R.,
Hempelmann G.
Publication year - 1984
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1984.tb02060.x
Subject(s) - medicine , diluent , citric acid , syringe , dilution , fluoride , heparin , blood sampling , blood gas analysis , chromatography , base (topology) , arterial blood , anesthesia , surgery , biochemistry , nuclear chemistry , inorganic chemistry , chemistry , mathematical analysis , physics , mathematics , psychiatry , thermodynamics
The results of acid‐base status and blood‐gas analysis can be influenced massively by incorrect sampling. We found that the addition of heparin has no great effect on blood‐gas measurement. Citric acid and fluoride can also be admixed to blood samples in the usual concentrations without severe side‐effects. The major error in the determination of blood gases and acid‐base status is a consequence of even minimal dilution: filling the deadspace of a syringe with any diluent leads to unacceptable results. Hence, we conclude that blood specimens for determination of blood gases and acid‐base status should be taken in specially prepared syringes containing the anticoagulant in the form of a dry substance. We think that citric acid is also acceptable for anticoagulation. Fluoride should be added in order to minimize alterations of pH due to anaerobic glycolysis.