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Pharmacokinetics and Placental Transmission of Fazadinium in Elective Caesarean Sections
Author(s) -
Rainaldi M. P.,
Busi T.,
Melloni C.,
Boschi S.
Publication year - 1984
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1984.tb02047.x
Subject(s) - medicine , obstetrics , pharmacokinetics , transmission (telecommunications) , placenta , elective caesarean section , caesarean section , pregnancy , fetus , biology , genetics , electrical engineering , engineering
The pharmacokinetics and placental transmission of fazadinium (0.75‐0.80 mg kg ‐1 ) were studied in seven pregnant women undergoing elective caesarean section. Plasma levels of the drug were determined by a spectrofluorimetric method and pharmacokinetics were derived according to a 2‐compartment open model. Distribution and elimination half‐lives averaged 0.07 ±0.03 (t½alpha) and 1.24 ± 0.34 (t½ beta) h; the volume of distribution was 20.75± 5.81 1, and the plasma clearance was 202.33 ± 39.2 ml min ‐1 1.73 m 2 . The ratio between umbilical venous blood and maternal blood at delivery ranged from 2.57 to 17.5%. Urinary elimination accounted for 37% of the injected dose within 24 h. It is concluded that because of early good intubating conditions and favourable pharmacokinetics with a modest placental passage, fazadinium might be particularly useful in obstetrics.