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The In Vitro Effect of Hypotensive Agents on the Affinity of Haemoglobin for Oxygen
Author(s) -
Jones R. M.,
Pollard B. J.,
Rowbottom S. J.,
Lovelock H. A.,
Borthwick J. M.
Publication year - 1984
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1984.tb02022.x
Subject(s) - sodium nitroprusside , medicine , propranolol , pharmacology , labetalol , anesthesia , oxygen , in vitro , blood pressure , biochemistry , nitric oxide , chemistry , organic chemistry
The effect of nitroglycerine, sodium nitroprusside, trimetaphan, pentolinium, labetalol and propranolol on the affinity of haemoglobin for oxygen was studied in vitro. Only pentolinium had a significant effect, increasing the binding of oxygen by haemoglobin. The significance of these results is discussed.