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Pharmacokinetics and Pharmacodynamics of Thiopental in Patients Undergoing Renal Transplantation
Author(s) -
Christensen J. H.,
Andreasen F.,
Jansen J.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01998.x
Subject(s) - medicine , pharmacokinetics , pharmacodynamics , pharmacology , transplantation , kidney transplantation , anesthesia
The effects and pharmacokinetics of thiopental were studied in eight patients undergoing renal transplantation. The results were compared with findings in a group of patients with normal renal function. No differences were observed in induction doses or between arterial or venous sleep concentrations. The average V 3 in the renal failure group was 1441 or 2.5 times the value of the control group ( P <0.01). The apparent differences indicating longer elimination half‐lives and higher serum clearances in the renal patients were not significant. The average binding of thiopental to serum protein shortly after the induction was 83.9 % (78.2–88.1) in the renal patients and 89.0% (85.2–91.6) in the control patients ( P <0.05). The difference in V 3 could be explained by the differences in protein binding and when the serum clearance was calculated by using the unbound fraction, this “intrinsic clearance” was significantly lower in the renal failure group ( P <0.05). Haemodynamic parameters were determined during the initial 5 min. No significant difference was observed between the thiopental‐induced changes in stroke volume. Cardiac output was unchanged in both patient groups.