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Haemodynamic Comparison of Dopamine and Dobutamine in Normovolaemic and Hypovolaemic Dogs
Author(s) -
Vainionpää V.,
Nuutinen L.,
Kairaluoma M.,
Mokka R.,
Tuon S.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01993.x
Subject(s) - dobutamine , medicine , hypovolemia , anesthesia , hemodynamics , blood pressure , cardiac output , diuresis , dopamine , diastole , aortic pressure , cardiology , kidney
The haemodynamic effects of dopamine and dobutamine in doses of 1–106 μg/kg/min were compared in dogs, first in the normovolaemic stale and then after bleeding (10 ml/kg). In normovolaemia, dopamine caused a dose‐dependent rise in systolic, mean and diastolic aortic pressures, while dobutamine caused a rise only in systolic pressure. In hypovolemia, a rise in all three aortic pressures was caused by both drugs, but to a lesser extent by dobutamine. Heart rate and cardiac output were similarly increased by both drugs, as was pulmonary artery pressure with high doses, in both states. Renal blood flow and diuresis increased in the middle‐dose area. Both inotropic drugs caused an elevation in Paco 2 and a drop in Pao 2 and O 2 ‐saturation in both normovolaemia and hypovolemia. The results agree with current opinion on the dose‐dependent alpha‐sympathomimetie action of dopamine and the relatively pure beta‐action of dobutamine.