Premium
Influence of Dixyrazine on Intestinal and Renal Vasoconstrictor Responses During Fentanyl‐Nitrous Oxide Anaesthesia
Author(s) -
Winsö O.,
Biber B.,
Holm C.,
Martner J.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01987.x
Subject(s) - medicine , vascular resistance , anesthesia , stimulation , diuresis , reflex , pentobarbital , fentanyl , nitrous oxide , kidney , endocrinology , hemodynamics
In cats (n=24) anaesthetized with fentanyl‐nitrous oxide and diazepam, stimulation of the hypothalamic defence‐alarm area (DA) or afferent activation of somatic pain fibres (SA), elicited a pronounced increase in intestinal (DA 297%, SA 107%) and renal (DA 214%, SA 90%) vascular resistance as well as a decrease in diuresis. These stress‐related responses were markedly counteracted by dixyrazine (0.15‐0.5 mg · kg ‐1 b.w. i.v.), especially in the kidney where the subsequent increase in vascular resistance to DA and SA stimulations amounted to only 25% and 13%, respectively, while diuresis increased. Corresponding data for stimulation‐induced increases in intestinal vascular resistance after dixyrazine were DA 156% and SA 28%. Dixyrazine is suggested to act both through interaction with peripheral α‐adrenergic mechanisms in control of vascular tone and through central nervous cardiovascular reflex depression. In man (n=7), during a similar form of anaesthesia, portal vein blood flow (1137±177 ml) was measured by the continuous thermodilution method. Preportal tissue vascular resistance during surgery decreased significantly (11.3 vs 8.7 kPa · min ml ‐1 · 10 ‐3 ) after i.v. dixyrazine (0.15mg · kg ‐1 b.w.). A concomitant increase in oxygen uptake in preportal tissues occurred (19.9 ml min ‐1 vs 24.5 ml · min ‐1 ).