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Plasma Cholinesterase Levels Following Pancuronium and Vecuronium
Author(s) -
MirakhurM.D. R. K.,
Ferres C. J.,
Lavery T. D.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01985.x
Subject(s) - medicine , cholinesterase , anesthesia , vecuronium bromide , pharmacology
Plasma cholinesterase levels were measured in 52 patients following administration of pancuronium 1 mg/70kg (10 patients) and 0.1 mg/kg (10 patients) and vecuronium in doses of 1 mg/70 kg (10 patients), 0.1 mg/kg (10 patients) and 0.2 mg/kg (12 patients). Both doses of pancuronium produced a significant ( P <0.05 ‐<0.005) reduction in the enzyme levels. Vecuronium in a dose of 1 mg/70 kg was without any significant effects but the two higher doses produced a dose‐related reduction of about 8 and 16% in the enzyme levels, respectively, which was statistically significant ( P <0.05 ‐<0.001).