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Stimulation of Drug‐Metabolizing Enzymes by Nitrous Oxide in the Rat
Author(s) -
Peduto V. A.,
Masini E.,
Ludovici M.,
Pieraccioli E.,
Dolara P.,
NovelliM.D G. P.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01983.x
Subject(s) - nitrous oxide , pentobarbital , demethylase , medicine , enzyme , xenobiotic , urinary system , pyrene , pharmacology , enzyme inducer , stimulation , endocrinology , biochemistry , anesthesia , chemistry , epigenetics , organic chemistry , gene
Wistar male rats were subchronically (150 h continuously) or chronically (5 h daily for 15 days) exposed to a 50% nitrous oxide/oxygen mixture. As an index of enzyme induction liver N‐demethylase and benzo(a)pyrene‐hydroxylase activities, serum γ‐glutamyltranspeptidase activity, urinary d‐glucaric acid and pentobarbital sleeping time were evaluated in comparison with a control group. No effect was observed after subchronic exposure to the anaesthetic gas. Chronic exposure, on the contrary, decreased pentobarbital sleeping time, increased urinary d‐glucaric acid, liver N‐demethylase and serum γ‐glutamyltranspeptidase activities. No increase of liver benzo(a)pyrene‐hydroxylase was observed. Chronic nitrous oxide exposure under appropriate conditions can modify some enzymes, metabolizing drugs and xenobiotic compounds.