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Tissue Distribution of Thiopental and Diazepam in Rats at 71 Atmospheres Pressure
Author(s) -
AanderudM.D L.,
Thoner J.,
Bakke O. M.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01982.x
Subject(s) - diazepam , medicine , kidney , distribution (mathematics) , anesthesia , endocrinology , mathematical analysis , mathematics
35 S‐thiopental 15 mg/kg and 14 C‐diazepam 5 mg/kg were injected intravenously in separate groups of rats (n=6) at 1 ATA air and at 71 ATA air‐He. Total radioactivity was measured in the brain, liver, kidney, muscle and fat after 1, 3, 5 and 15 min. The thiopental content was significantly reduced at pressure in the brain at 3, 5 and 15 min. The diazepam content of the brain was significantly reduced at pressure at 1, 5 and 15 min. The liver, muscle and kidney tissue generally contained slightly less of either drug at pressure, particularly at the earliest sampling times.