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The Effects of Intravenous Lorazepam Alone and with Meperidine on Ventilation in Man
Author(s) -
Paulson B. A.,
Becker L. D.,
Way W. L.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01976.x
Subject(s) - lorazepam , medicine , anesthesia , benzodiazepine , ventilation (architecture) , morphine , depression (economics) , respiratory system , respiratory minute volume , mechanical engineering , receptor , engineering , economics , macroeconomics
The respiratory effects of lorazepam (a 1, 4 benzodiazepine) were studied using a modified Read rebreathing technique in healthy adult males about to undergo elective surgery. Lorazepam 0.05 mg/kg (IV) produced an increase in slope and a shift to the left of the CO 2 response curve. These effects were also detectable but of smaller magnitude when the same lorazepam dose (IV) was given with meperidine (IV). End‐expiratory CO 2 (Peco 2 ), which was significantly elevated in all drug groups, is not a sensitive indicator of either the time course or the degree of respiratory depression.