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Respiratory Effect of THIP, a GABA‐Agonistic Analgesic, During Halothane Anaesthesia
Author(s) -
Valentin N.,
BankMikkelsen O. K.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01969.x
Subject(s) - medicine , analgesic , anesthesia , halothane , respiratory system , agonistic behaviour , ventilation (architecture) , general anaesthesia , mechanical engineering , psychiatry , engineering , aggression
THIP, 4, 5, 6, 7‐tetrahydroisoxazolo (5, 4‐) pyridin‐3‐ol, is a GABA‐agonistic drug with analgesic effect, but apparently without respiratory depressant properties in awake subjects. The effect of THIP on the CO 2 ventilation response was tested before, during and at the end of halothane anaesthesia in six male patients and compared to a control group. As there was no indication of respiratory depression by THIP, the drug may have a future in the treatment of postoperative pain if an analgesic effect is confirmed under clinical conditions.