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Anaesthetic Uptake by the Goldfish: Effect of Respiratory Rate
Author(s) -
Chalon J.,
Martin P.,
Roberts C.,
Ramanathan S.,
Katz R.,
Turndorf H.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01968.x
Subject(s) - medicine , respiratory system , anesthesia , intensive care medicine
In order to assess the uptake of halothane by the goldfish, the respiratory rate of six fish was studied when water temperature was varied with and without changes in oxygen or carbon dioxide tension. The effective dose 50 of halothane (ED‐50‐H) and the time taken to reach it (T‐ED‐50‐H) at an Fio 2 of 0.35 in nitrogen, were studied when temperature and CO 2 tension were varied. Nomograms were drawn to predict respiratory rate as a function of water CO 2 tension, when CO 2 was bubbled in air or in oxygen, and with changes in water temperature. At low temperatures (5°C to 7.5°C), respiratory rate remained below 10 per min, irrespective of CO 2 partial pressure. At28°C, a CO 2 partial pressure of 8 ±0.2 kPa produced a respiratory rate of 125±3/min in air, and in oxygen unexpectedly 140±3/min. Halothane ED‐50 varied with temperature (0.8% at 10°C and 1.6% at 23°C). Time to reach ED‐50‐H decreased with increases in respiratory rate, but increased as water temperature was elevated.