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Effects of Prenalterol on Central Haemodynamics and V A /Q Distribution Early after Open‐Heart Surgery
Author(s) -
AnjouLindskog E.,
Broman L.,
Holmgren A.,
Wedelin B.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01924.x
Subject(s) - medicine , cardiac output , hemodynamics , perfusion , anesthesia , hypoxic pulmonary vasoconstriction , pulmonary wedge pressure , shunt (medical) , cardiology , aortic pressure , cardiac function curve , pulmonary artery , heart failure
The effects of intravenous injection of prenalterol, a selective β 1 ,‐adrenoceptor agonist, on central haemodynamics and the distribution of ventilation‐perfusion (V̇ A /Q̇) were assessed in eight patients alter aortic and/or mitral valve replacement. V̇ A /Q̇ distributions were determined by the multiple inert gas elimination technique. Administration of prenalterol resulted in a significant increase in cardiac output and heart rate with no changes in mean pulmonary arterial pressure and wedge pressure. There was an insignificant fall in arterial oxygen tension from 14.3 to 12.4 kPa, accompanied by a significant increase in the inert gas shunt from 6.4 to 11.3% of cardiac output, while the configuration of the distributions of perfusion and ventilation on V̇ A /Q̇, remained unchanged. The increase in shunt was probably more an effect of the increase in cardiac output than a direct effect of the drug on the pulmonary vascular bed.