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Effects of Working Environment on the Liver in 10 Anaesthetists
Author(s) -
Rosenberg P. H.,
Oikkonen M.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01922.x
Subject(s) - medicine , alkaline phosphatase , urine , hbsag , enzyme , alanine aminotransferase , transferase , physiology , endocrinology , biochemistry , immunology , hepatitis b virus , chemistry , virus
Drug‐metabolising ability, i.e. antipyrine half‐life, in anaesthetists was significantly slowed (23%) at the end of summer vacation (2–4 weeks), as compared to prevacation values. Despite changes in either direction, the antipyrine half‐lives, including four determinations within a year and a half from the ten anaesthetists, were within normal limits. Liver enzymes (aspartate aminotransferase, alanine amino‐transferase, alkaline phosphatase) were also normal. In one anaesthetist the test for anti‐HBsAg was positive in 1980, while in the others HBsAg and anti‐HBsAg were negative in 1980 and 1981. The inorganic fluoride concentrations of serum and urine (determined four times) were at normal levels. Only in one anaesthetist was there a transient, surprisingly high, serum concentration (7.9 μp.mol/l), apparently unrelated to work exposure.