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Effect of Age on the Establishment of Muscle Paralysis Induced in Anaesthetized Adult Subjects by ORG NC 45
Author(s) -
D'Hollander A. A.,
Nevelsteen M.,
Barvais L.,
Baurain M.
Publication year - 1983
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1983.tb01916.x
Subject(s) - medicine , isometric exercise , paralysis , depression (economics) , adductor pollicis muscle , anesthesia , latency (audio) , surgery , elbow , ulnar nerve , economics , macroeconomics , electrical engineering , engineering
The establishment of muscle paralysis produced by a single dose of 70 μg · kg ‐1 of ORG NC 45 was studied in 30 healthy anaesthetized patients, aged 15–85 years, by recording adductor pollicis isometric mechanical activity‐twitch height (TH). Significant correlations were observed between age and the latency of ORG NC45 action, defined as the reduction of TH to 95% of its initial value (r: 0.315, P <0.05)and between age and the onset time, defined as the time elapsing between ORG NC 45 administration and maximum TH depression observed (r: 0.454, P <0.005). Correlation between age and maximum TH depression was not significant. These results show that if the maximum TH depression observed after a standard dose of ORG NC 45 is not altered by the age of the patient, the establishment of the paralysis is delayed by ageing.